Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

doi:10.1210/jc.2007-2218

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Article

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

The Journal of clinical endocrinology and metabolism - 1 May 2008

Stancáková Alena, Pihlajamäki Jussi, Kuusisto Johanna, Stefan Norbert, Fritsche Andreas, Häring Hans, Andreozzi Francesco, Succurro Elena, Sesti Giorgio, Boesgaard Trine Welløv, Hansen Torben, Pedersen Oluf, Jansson Per Anders, Hammarstedt Ann, Smith Ulf, Laakso Markku

Abstract excerpt

CONTEXT: CDKAL1 is a recently discovered susceptibility gene for type 2 diabetes. OBJECTIVE: Our objective was to investigate the impact of rs7754840 of CDKAL1 on insulin secretion, insulin sensitivity, and risk of type 2 diabetes. DESIGN AND SETTINGS: Study 1 (the EUGENE2 study) was a cross-sectional study including subjects from five white populations in Europe (Denmark, Finland, Germany, Italy, and Sweden)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18285412
DOI: 10.1210/jc.2007-2218

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CDKAL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.PMID 18285412Read ↗

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