A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.

doi:10.1038/ng2043

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.

Nature genetics - 1 Jun 2007

Steinthorsdottir Valgerdur, Thorleifsson Gudmar, Reynisdottir Inga, Benediktsson Rafn, Jonsdottir Thorbjorg, Walters G Bragi, Styrkarsdottir Unnur, Gretarsdottir Solveig, Emilsson Valur, Ghosh Shyamali, Baker Adam, Snorradottir Steinunn, Bjarnason Hjordis, Ng Maggie C Y, Hansen Torben, Bagger Yu, Wilensky Robert L, Reilly Muredach P, Adeyemo Adebowale, Chen Yuanxiu, Zhou Jie, Gudnason Vilmundur, Chen Guanjie, Huang Hanxia, Lashley Kerrie, Doumatey Ayo, So Wing-Yee, Ma Ronald C Y, Andersen Gitte, Borch-Johnsen Knut, Jorgensen Torben, van Vliet-Ostaptchouk Jana V, Hofker Marten H, Wijmenga Cisca, Christiansen Claus, Rader Daniel J, Rotimi Charles, Gurney Mark, Chan Juliana C N, Pedersen Oluf, Sigurdsson Gunnar, Gulcher Jeffrey R, Thorsteinsdottir Unnur, Kong Augustine, Stefansson Kari

Abstract excerpt

We conducted a genome-wide association study for type 2 diabetes (T2D) in Icelandic cases and controls, and we found that a previously described variant in the transcription factor 7-like 2 gene (TCF7L2) gene conferred the most significant risk. In addition to confirming two recently identified r...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Insulin

Share to Insulin Resistance

Share to Insulin Secretion

Share to Intracellular Signaling Peptides and Proteins

Share to TCF Transcription Factors

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed

Identifiers

PMID: 17460697
DOI: 10.1038/ng2043

Genes

CDKAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17460697-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.PMID 17460697Read ↗

Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.Semantic proximity Read ↗

TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals.Semantic proximity Read ↗

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.Semantic proximity Read ↗

Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.Semantic proximity Read ↗

What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us About the Pathogenesis of Type 2 Diabetes?Semantic proximity Read ↗

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.Semantic proximity Read ↗

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.Semantic proximity Read ↗

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals.Semantic proximity Read ↗

Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.Semantic proximity Read ↗

Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.Semantic proximity Read ↗

TCF7L2 genetic defect and type 2 diabetes.Semantic proximity Read ↗

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.