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Article

A defect of LigD (human Lig4 homolog) for nonhomologous end joining significantly improves efficiency of gene-targeting in Aspergillus oryzae.

Fungal genetics and biology : FG & B - 1 Jun 2008

Mizutani Osamu, Kudo Youhei, Saito Akemi, Matsuura Tomomi, Inoue Hirokazu, Abe Keietsu, Gomi Katsuya

Abstract excerpt

Gene-targeting by homologous recombination occurs rarely during transformation since nonhomologous recombination is predominant in Aspergillus oryzae. To develop a highly efficient gene-targeting system for A. oryzae, we constructed disrupted strains harboring a gene (ligD) encoding human DNA ligase IV homolog that is involved in the final step of DNA nonhomologous end joining. The A. oryzae ligD disruptants...

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Identifiers

PMID: 18282727
DOI: 10.1016/j.fgb.2007.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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