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A Defect in DNA Ligase4 Enhances the Frequency of TALEN-Mediated Targeted Mutagenesis in Rice.

Plant physiology - 1 Feb 2016

Nishizawa-Yokoi Ayako, Cermak Tomas, Hoshino Tomoki, Sugimoto Kazuhiko, Saika Hiroaki, Mori Akiko, Osakabe Keishi, Hamada Masao, Katayose Yuichi, Starker Colby, Voytas Daniel F, Toki Seiichi

Abstract excerpt

We have established methods for site-directed mutagenesis via transcription activator-like effector nucleases (TALENs) in the endogenous rice (Oryza sativa) waxy gene and demonstrated stable inheritance of TALEN-induced somatic mutations to the progeny. To analyze the role of classical nonhomologous end joining (cNHEJ) and alternative nonhomologous end joining (altNHEJ) pathways in TALEN-induced mutagenesis in...

Topics

DNA Breaks, Double-Stranded
DNA End-Joining Repair
DNA Ligases
DNA, Plant
Mutagenesis, Site-Directed
Mutation
Oryza
Plant Proteins
Plants, Genetically Modified
Transcription Activator-Like Effector Nucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26668331
DOI: 10.1104/pp.15.01542
PMCID: PMC4734567

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