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Article

Improved gene targeting frequency in marine-derived filamentous fungus Aspergillus glaucus by disrupting ligD.

Journal of applied genetics - 1 Aug 2012

Fang Zhe, Zhang Ying, Cai Menghao, Zhang Jian, Zhang Yuanxing, Zhou Xiangshan

Abstract excerpt

Filamentous fungi from the marine environment have shown great potential as cell factories for the production of pharmacologically active metabolites, but extremely low frequency of homologous recombination brings difficulty to further molecular biology studies. To bypass this problem and develop a highly efficient gene targeting system in marine-derived filamentous fungus Aspergillus glaucus, LigD, a homolog of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22562375
DOI: 10.1007/s13353-012-0095-z

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