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Article

An evaluation of the role of LIG4 in genomic instability and adaptive mutagenesis in Candida albicans.

FEMS yeast research - 1 Aug 2002

Andaluz Encarnación, Ciudad Toni, Larriba Germán

Abstract excerpt

The non-homologous end-joining (NHEJ) pathway of DNA recombination is important for genomic stability in animal cells, since the absence of Ku70, Ku80, Lig4 or Xrcc4 results in non-reciprocal translocation and chromosome fragmentation. The role of LIG4 in the genomic instability of Candida albicans has been analyzed. We have found that both cell transformation and 5'-fluoroorotic acid selection steps used to...

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Share to Candida albicans
Share to Chromosomes, Fungal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Ligase ATP

Share to DNA Ligases

Share to Electrophoresis, Gel, Pulsed-Field

Share to Mutagenesis

Share to Translocation, Genetic

Source

Identifiers

PMID: 12702284
DOI: 10.1016/S1567-1356(02)00094-6

Genes

LIG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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