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Article

Remote mutations alter transition-state structure of human purine nucleoside phosphorylase.

Biochemistry - 26 Feb 2008

Luo Minkui, Li Lei, Schramm Vern L

Abstract excerpt

Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine (2'-deoxy)ribonucleosides to give the corresponding purine base and (2'-deoxy)ribose 1-phosphate as products. Human and bovine PNPs (HsPNP and BtPNP) form distinct transition states despite 87% identity in amino acid sequence. A PNP hybrid was produced by replacing K22 and H104 in HsPNP with the corresponding Glu and Arg...

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Source

Identifiers

PMID: 18281957
DOI: 10.1021/bi702133x

Genes

PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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