Article
Common hydrogen bond interactions in diverse phosphoryl transfer active sites.
PloS one - 1 Jan 2014
Summerton Jean C, Martin Gregory M, Evanseck Jeffrey D, Chapman Michael S
Abstract excerpt
Phosphoryl transfer reactions figure prominently in energy metabolism, signaling, transport and motility. Prior detailed studies of selected systems have highlighted mechanistic features that distinguish different phosphoryl transfer enzymes. Here, a top-down approach is developed for comparing statistically the active site configurations between populations of diverse structures in the Protein Data Bank, and it...
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