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Article

Thermodynamics of the Purine Nucleoside Phosphorylase Reaction Revealed by Computer Simulations.

Biochemistry - 10 Jan 2017

Isaksen Geir Villy, Åqvist Johan, Brandsdal Bjørn Olav

Abstract excerpt

Enzymes are able to catalyze chemical reactions by reducing the activation free energy, yielding significant increases in the reaction rates. This can thermodynamically be accomplished by either reducing the activation enthalpy or increasing the activation entropy. The effect of remote mutations on the thermodynamic activation parameters of human purine nucleoside phosphorylase is examined using extensive...

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Identifiers

PMID: 27976868
DOI: 10.1021/acs.biochem.6b00967

Genes

PNP
ADO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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