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Article

A conserved loop in polynucleotide phosphorylase (PNPase) essential for both RNA and ADP/phosphate binding.

Biochimie - 1 Feb 2014

Carzaniga Thomas, Mazzantini Elisa, Nardini Marco, Regonesi Maria Elena, Greco Claudio, Briani Federica, De Gioia Luca, Dehò Gianni, Tortora Paolo

Abstract excerpt

Polynucleotide phosphorylase (PNPase) reversibly catalyzes RNA phosphorolysis and polymerization of nucleoside diphosphates. Its homotrimeric structure forms a central channel where RNA is accommodated. Each protomer core is formed by two paralogous RNase PH domains: PNPase1, whose function is largely unknown, hosts a conserved FFRR loop interacting with RNA, whereas PNPase2 bears the putative catalytic site, ∼20...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24075876
DOI: 10.1016/j.biochi.2013.09.018

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