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Article

A small ribozyme with dual-site kinase activity.

Nucleic acids research - 1 Aug 2012

Biondi Elisa, Maxwell Adam W R, Burke Donald H

Abstract excerpt

Phosphoryl transfer onto backbone hydroxyls is a recognized catalytic activity of nucleic acids. We find that kinase ribozyme K28 possesses an unusually complex active site that promotes (thio)phosphorylation of two residues widely separated in primary sequence. After allowing the ribozyme to radiolabel itself by phosphoryl transfer from [γ-(32)P]GTP, DNAzyme-mediated cleavage yielded two radiolabeled cleavage...

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Identifiers

PMID: 22618879
DOI: 10.1093/nar/gks356
PMCID: PMC3424543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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