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Article

Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase.

Biochemistry - 26 Feb 2008

Ghanem Mahmoud, Li Lei, Wing Corin, Schramm Vern L

Abstract excerpt

Human (HsPNP) and bovine (BtPNP) purine nucleoside phosphorylases are homotrimers with the catalytic sites located near the subunit-subunit interfaces. Despite the high amino acid sequence similarity (87% identical) and the fully conserved catalytic site contacts between BtPNP and HsPNP, crystal structures reveal that the subunits interact differently and isotope effect studies indicate distinct transition-state...

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Identifiers

PMID: 18281956
DOI: 10.1021/bi702132e

Genes

PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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