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Article

Phosphatidylinositol synthesis is essential in bloodstream form Trypanosoma brucei.

The Biochemical journal - 1 Jun 2006

Martin Kirstee L, Smith Terry K

Abstract excerpt

PI (phosphatidylinositol) is a ubiquitous eukaryotic phospholipid which serves as a precursor for messenger molecules and GPI (glycosylphosphatidylinositol) anchors. PI is synthesized either de novo or by head group exchange by a PIS (PI synthase). The synthesis of GPI anchors has previously been validated both genetically and chemically as a drug target in Trypanosoma brucei, the causative parasite of African...

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Source

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Identifiers

PMID: 16475982
DOI: 10.1042/BJ20051825
PMCID: PMC1462709

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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