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Article

Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue.

Frontiers in immunology - 1 Jan 2023

Talaie Tara, Wang Hui, Kuo Wan-I, Danzl Nichole, Gulsen Mert R, Wolabaugh Amber N, Ding Xiaolan, Sykes Megan, Li Hao Wei

Abstract excerpt

Robust human immune system (HIS) mice are created using human fetal thymus tissue and hematopoietic stem cells (HSCs). A HIS mouse model using neonatal human thymus tissue and umbilical cord blood (CB) HSCs (NeoHu) was recently described. We improved the model by removing the native murine thymus, which can also generate human T cells, and demonstrated definitively the capacity of human T cells to develop in a...

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Identifiers

PMID: 37251390
DOI: 10.3389/fimmu.2023.1159341
PMCID: PMC10213218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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