Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severe combined immunodeficiency. A model disease for molecular immunology and therapy

17 Jan 2005

Abstract excerpt

Severe combined immunodeficiencies (SCIDs) consist of genetically determined arrest of T-cell differentiation. Ten different molecular defects have now been identified, which all lead to early death in the absence of therapy. Transplantation of allogeneic hematopoietic stem cells (HSCT) can restore T-cell development, thus saving the lives of SCID patients. In this review, the different characteristics of HSCT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immunodeficiency and Autoimmune Disorders
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15661024
DOI: 10.1111/j.0105-2896.2005.00223.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe combined immunodeficiency. A model disease for molecular immunology and therapyPMID 15661024Read ↗

Gene therapy for severe combined immunodeficiency.Semantic proximity Read ↗

Severe combined immunodeficiency: From its discovery to the perspective.Semantic proximity Read ↗

Severe combined immunodeficiencies (SCID).Semantic proximity Read ↗

Delayed presentation of severe combined immunodeficiency due to prolonged maternal T cell engraftment.Semantic proximity Read ↗

Severe combined immunodeficiences: new and old scenarios.Semantic proximity Read ↗

Identification of checkpoints in human T-cell development using severe combined immunodeficiency stem cells.Semantic proximity Read ↗

Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiencySemantic proximity Read ↗

Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency.Semantic proximity Read ↗

Modern management of primary T-cell immunodeficiencies.Semantic proximity Read ↗

iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental ArrestsSemantic proximity Read ↗

Gene therapy for severe combined immunodeficiency: are we there yet?Semantic proximity Read ↗

Haematopoietic stem cell transplantation for <scp>SCID</scp> patients: where do we stand?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.