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Article

Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice.

The Journal of experimental medicine - 1 Dec 1992

Vandekerckhove B A, Baccala R, Jones D, Kono D H, Theofilopoulos A N, Roncarolo M G

Abstract excerpt

Implantation of pieces of human fetal liver and thymus into SCID mice results in the development of a human thymus-like organ, in which sustained lymphopoiesis is reproducibly observed. In this model, T cell development can be experimentally manipulated. To study the influence of thymic selection on the development of the human T cell repertoire, the T cell receptor (TCR) V beta gene repertoire of double-positive...

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Identifiers

PMID: 1460421
DOI: 10.1084/jem.176.6.1619
PMCID: PMC2119440

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Source receipt: pubmed, retrieved 7 Sept 2026.

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