Article
Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice.
The Journal of experimental medicine - 1 Dec 1992
Vandekerckhove B A, Baccala R, Jones D, Kono D H, Theofilopoulos A N, Roncarolo M G
Abstract excerpt
Implantation of pieces of human fetal liver and thymus into SCID mice results in the development of a human thymus-like organ, in which sustained lymphopoiesis is reproducibly observed. In this model, T cell development can be experimentally manipulated. To study the influence of thymic selection...
Topics
- Alleles
- Animals
- CD4 Antigens
- CD8 Antigens
- Fetal Tissue Transplantation
- Humans
- Liver Transplantation
- Mice
- Mice, SCID
- RNA, Messenger
- Receptors, Antigen, T-Cell
- T-Lymphocytes
- Thymus Gland
- Transcription, Genetic