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Article

Tau haplotypes regulate transcription and are associated with Parkinson's disease.

Annals of neurology - 1 Mar 2004

Kwok John B J, Teber Erdahl T, Loy Clement, Hallupp Marianne, Nicholson Garth, Mellick George D, Buchanan Daniel D, Silburn Peter A, Schofield Peter R

Abstract excerpt

A primary haplotype (H1) of the microtubule-associated protein Tau (MAPT) gene is associated with Parkinson's disease (PD). However, the mechanism for disease susceptibility remains unknown. We examined the promoter region of MAPT and identified single nucleotide polymorphisms and insertions of 1 to 11 nucleotides. These polymorphisms corresponded to the previously characterized haplotypes, H1 and H2, as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14991810
DOI: 10.1002/ana.10826

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tau haplotypes regulate transcription and are associated with Parkinson's disease.PMID 14991810Read ↗

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The tau gene haplotype h1 confers a susceptibility to Parkinson's disease.Semantic proximity Read ↗

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