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Article

The p53 R72P polymorphism does not affect the physiological response to ionizing radiation in a mouse model.

Cell cycle (Georgetown, Tex.) - 18 Jun 2017

Domínguez Emily R, Orona Jennifer, Lin Kevin, Pérez Carlos J, Benavides Fernando, Kusewitt Donna F, Johnson David G

Abstract excerpt

Tissue culture and mouse model studies show that the presence of the arginine (R) or proline (P) coding single nucleotide polymorphism (SNP) of the tumor suppressor gene p53 at codon 72 (p53 R72P) differentially affects the responses to genotoxic insult. Compared to the P variant, the R variant shows increased apoptosis in most cell cultures and mouse model tissues in response to genotoxins, and epidemiological...

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Identifiers

PMID: 28594296
DOI: 10.1080/15384101.2017.1312234
PMCID: PMC5499914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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