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p53 codon 72 polymorphism, DNA damage and repair, and risk of non-melanoma skin cancer.

Mutation research - 1 Jun 2007

Bendesky Andres, Rosales Alejandra, Salazar Ana María, Sordo Monserrat, Peniche Jorge, Ostrosky-Wegman Patricia

Abstract excerpt

A very common polymorphism of p53, that of codon 72, codes either for a proline (P72) or an arginine (R72). The two alleles differ in their biological properties: P72 is a stronger inducer of p21, while R72 induces 5-10 times more apoptosis. It is not known, however, whether this polymorphism influences genome stability. The influence of p53 codon 72 polymorphism on cancer risk has been studied for different...

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Identifiers

PMID: 17403527
DOI: 10.1016/j.mrfmmm.2007.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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