Article
K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
Lung cancer (Amsterdam, Netherlands) - 1 Jul 2003
Keohavong Phouthone, Lan Qin, Gao Wei-Min, DeMarini David M, Mass Marc J, Li Xue-Ming, Roop Barbara C, Weissfeld Joel, Tian Defa, Mumford Judy L
Abstract excerpt
Lung cancer mortality rate in nonsmoking women in Xuan Wei (XW) County is the highest in China. The XW lung cancer rate is associated with exposure to coal smoke, containing high concentrations of polycyclic aromatic hydrocarbons (PAHs), in unvented homes. Here we investigated codon 12 K-ras mutations in lung tumors or sputum samples from 102 XW lung cancer patients (41 nonsmoking women and 61 smoking men). In...
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