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[Reduced Ca2+ current in rat cardiomyocytes transfected with troponin I R145W mutation gene].

Zhonghua xin xue guan bing za zhi - 1 Nov 2007

Wu Heng-Fang, Chen Xiang-Jian, Yang Di

Abstract excerpt

OBJECTIVE: To investigate the effects of cardiac troponin I R145W mutation, detected in Chinese patients with hypertrophic cardiomyopathy, on Ca(2+) current modulation. METHODS: R146W mutation (resemble R145W in human) was introduced into rat cardiac troponin I cDNA by site-directed mutagenesis. With EGFP as a reporter gene, replication-defective adenovirus containing the wild or mutant cTnI gene was constructed....

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Share to Calcium Channels, L-Type
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

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Share to Rats, Sprague-Dawley

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Source

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PMID: 18269819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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