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Article

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes.

Pflugers Archiv : European journal of physiology - 1 Oct 2008

Reis Stephanie, Littwitz Christoph, Preilowski Sebastian, Mügge Andreas, Stienen Ger J M, Pott Lutz, Jaquet Kornelia

Abstract excerpt

The R145G amino acid exchange in the inhibitory subunit (cTnI) of cardiac troponin, which regulates muscle contraction, is related to familial hypertrophic cardiomyopathy. Information on its impact on contractility of adult cardiomyocytes is scarce. We studied shortening of adult rat cardiomyocytes before and during ss-adrenergic stimulation using adenovirus-driven expression of human cTnI-wild type (wt) and...

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PMID: 18548271
DOI: 10.1007/s00424-008-0487-4

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Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes.PMID 18548271Read ↗

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