Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy.

The Journal of biological chemistry - 5 Apr 2002

Lang Rosalyn, Gomes Aldrin V, Zhao Jiaju, Housmans Philippe R, Miller Todd, Potter James D

Abstract excerpt

Familial hypertrophic cardiomyopathy has been associated with several mutations in the gene encoding human cardiac troponin I (HCTnI). A missense mutation in the inhibitory region of TnI replaces an arginine residue at position 145 with a glycine and cosegregates with the disease. Results from se...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Hypertrophic, Familial
Share to Circular Dichroism
Share to Muscle Contraction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Fibers, Skeletal

Share to Myosins

Share to Stress, Mechanical

Share to Troponin

Share to Troponin I

Source

Identifiers

PMID: 11801593
DOI: 10.1074/jbc.M108912200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11801593-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy.PMID 11801593Read ↗

Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils.Semantic proximity Read ↗

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.Semantic proximity Read ↗

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice.Semantic proximity Read ↗

Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development.Semantic proximity Read ↗

Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Effect of Arg145Gly mutation in human cardiac troponin I on the ATPase activity of cardiac myofibrils.Semantic proximity Read ↗

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes.Semantic proximity Read ↗

[Reduced Ca2+ current in rat cardiomyocytes transfected with troponin I R145W mutation gene].Semantic proximity Read ↗

Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.Semantic proximity Read ↗

Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.