Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation.

doi:10.1093/europace/euac091

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Article

Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology - 9 Dec 2022

Zhong Rujia, Zhang Feng, Yang Zhen, Li Yingrui, Xu Qiang, Lan Huan, Cyganek Lukas, El-Battrawy Ibrahim, Zhou Xiaobo, Akin Ibrahim, Borggrefe Martin

Abstract excerpt

AIMS: A loss-of-function mutation in L-type calcium (Ca2+) channel subunit gene CACNB2 has been reported to cause short QT syndrome subtype 5 (SQT5). However, the mechanism underlying the loss-of-function of the Ca2+ channel has not been clarified. In the present study, we aim to explore the DNA methylation mechanism of L-type Ca2+ channel downregulation in human-induced pluripotent stem cell-derived...

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PMID: 35894107
DOI: 10.1093/europace/euac091

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