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CLINICAL SIGNIFICANCE OF BRCA1 GENE SEQUENCING AND ITS PROMOTER METHYLATION TESTING IN THE SEARCH STRATEGY FOR THERAPEUTIC TARGETS IN BREAST CANCER TREATMENT.

Experimental oncology - 11 Oct 2023

Fishchuk L, Lobanova O, Rossokha Z, Cheshuk V, Vereshchako R, Vagyn Yu, Kashuba V, Vershyhora V, Popova O, Levkovich N, Zemlianska O, Ievseienkova O, Podolska S, Gorovenko N

Abstract excerpt

BACKGROUND: Currently, there is a great interest in the genetic testing of BRCA1 and BRCA2 due to the fact that for patients with breast cancer (BC) with pathogenic variants of these genes, the use of the PARP inhibitors could be also provided in addition to implemented treatment protocols. The aim of this study was to characterize the molecular genetic structure of the BRCA1 gene in BC patients without...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37824776
DOI: 10.15407/exp-oncology.2023.02.161

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