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Article

Prognostic value of BRCA1 promoter methylation for patients with epithelial ovarian cancer.

Journal of gynecology obstetrics and human reproduction - 1 Sept 2024

Azaïs Henri, Garinet Simon, Benoit Louise, de Jesus Julie, Zizi Mohamed, Landman Samuel, Bats Anne-Sophie, Taly Valérie, Laurent-Puig Pierre, Blons Hélène

Abstract excerpt

OBJECTIVE: BRCA1 promoter methylation (BRCA1pm) is suspected to alter prognosis of patients with epithelial ovarian cancer (EOC). We aimed to evaluate the prognostic impact of this epigenetic modification. METHODS: We conducted a retrospective, monocentric study from 11/2006 to 08/2018. Patients with EOC and available status concerning somatic BRCA1/2 mutation and BRCA1pm were included. Three groups were defined:...

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PMID: 38729429
DOI: 10.1016/j.jogoh.2024.102796

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