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Article

A systematic review on the frequency of BRCA promoter methylation in breast and ovarian carcinomas of BRCA germline mutation carriers: Mutually exclusive, or not?

Critical reviews in oncology/hematology - 1 Jul 2018

Vos Shoko, van Diest Paul Joannes, Moelans Cathy Beatrice

Abstract excerpt

BACKGROUND: A considerable number of breast and ovarian carcinomas are due to underlying BRCA gene aberrations. Of these, BRCA germline mutations and BRCA promoter methylation are thought to be mutually exclusive, which could be exploited in clinical practice. However, this paradigm has not been studied extensively and systematically. OBJECTIVE: To systematically investigate to what extent BRCA promoter...

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Identifiers

PMID: 29891109
DOI: 10.1016/j.critrevonc.2018.05.008

Genes

BRCA1
BRCA2

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