Article
The Study on the Role and Mechanism of HMGB1-Mediated TLR4/NLRP3/Caspase-1 Signaling Pathway in Regulating Cardiomyocyte Pyroptosis and Myocardial Injury Induced by Myocardial Infarction
2026-06-03
Abstract excerpt
<title>Abstract</title> <p>Background Despite undergoing primary percutaneous coronary intervention (PCI), approximately 65% of ST-segment elevation myocardial infarction (STEMI) patients still fail to achieve optimal myocardial reperfusion, with the "no-reflow" phenomenon being a key contributor. Previous studies have demonstrated that pyroptosis plays a critical role in cardiac disease progression, suggesting...
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Identifiers and source
- Literature Corpus work
- e0c4f2d1-7579-5b66-ae65-551f57931223
- DOI
- 10.21203/rs.3.rs-9514357/v1