Article
S100A9 Links Inflammation and Repair in Myocardial Infarction.
Circulation research - 14 Aug 2020
Marinković Goran, Koenis Duco Steven, de Camp Lisa, Jablonowski Robert, Graber Naomi, de Waard Vivian, de Vries Carlie Jacoba, Goncalves Isabel, Nilsson Jan, Jovinge Stefan, Schiopu Alexandru
Abstract excerpt
RATIONALE: The alarmin S100A9 has been identified as a potential therapeutic target in myocardial infarction. Short-term S100A9 blockade during the inflammatory phase post-myocardial infarction inhibits systemic and cardiac inflammation and improves cardiac function long term. OBJECTIVE: To evaluate the impact of S100A9 blockade on postischemic cardiac repair. METHODS AND RESULTS: We assessed cardiac function,...
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