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Article

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2001

Kamynina E, Debonneville C, Bens M, Vandewalle A, Staub O

Abstract excerpt

Liddle's syndrome is a form of inherited hypertension linked to mutations in the genes encoding the epithelial Na+ channel (ENaC). These mutations alter or delete PY motifs involved in protein-protein interactions with a ubiquitin-protein ligase, Nedd4. Here we show that Na+ transporting cells, derived from mouse cortical collecting duct, express two Nedd4 proteins with different structural organization and...

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Source

Identifiers

PMID: 11149908
DOI: 10.1096/fj.00-0191com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.PMID 11149908Read ↗

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.Semantic proximity Read ↗

Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.Semantic proximity Read ↗

Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.Semantic proximity Read ↗

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.Semantic proximity Read ↗

Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.Semantic proximity Read ↗

NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.Semantic proximity Read ↗

Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.Semantic proximity Read ↗

Expression, Transcription, and Possible Antagonistic Interaction of the Human Nedd4L Gene VariantSemantic proximity Read ↗

Transcriptional diversity and expression of NEDD4L gene in distal nephron.Semantic proximity Read ↗

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuliSemantic proximity Read ↗

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.Semantic proximity Read ↗

NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.Semantic proximity Read ↗

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