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Article

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

The Journal of clinical investigation - 1 Mar 1999

Abriel H, Loffing J, Rebhun J F, Pratt J H, Schild L, Horisberger J D, Rotin D, Staub O

Abstract excerpt

Liddle's syndrome is an inherited form of hypertension linked to mutations in the epithelial Na+ channel (ENaC). ENaC is composed of three subunits (alpha, beta, gamma), each containing a COOH-terminal PY motif (xPPxY). Mutations causing Liddle's syndrome alter or delete the PY motifs of beta- or...

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Source

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Identifiers

PMID: 10074483
DOI: 10.1172/JCI5713
PMCID: PMC408130

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10074483-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.PMID 10074483Read ↗

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.Semantic proximity Read ↗

Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.Semantic proximity Read ↗

Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.Semantic proximity Read ↗

Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.Semantic proximity Read ↗

Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.Semantic proximity Read ↗

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.Semantic proximity Read ↗

Expression, Transcription, and Possible Antagonistic Interaction of the Human Nedd4L Gene VariantSemantic proximity Read ↗

Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system.Semantic proximity Read ↗

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2.Semantic proximity Read ↗

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.Semantic proximity Read ↗

Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.Semantic proximity Read ↗

Association of NEDD4L ubiquitin ligase with essential hypertension.Semantic proximity Read ↗

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