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Article

Association of NEDD4L ubiquitin ligase with essential hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Sept 2005

Russo Christopher J, Melista Efthymia, Cui Jing, DeStefano Anita L, Bakris George L, Manolis Athanasios J, Gavras Haralambos, Baldwin Clinton T

Abstract excerpt

NEDD4L is a ubiquitin ligase that controls cell surface expression of kidney epithelial Na+ channels by ubiquitin-mediated endocytosis and lysosome targeting. Thus, it is a significant determinant of Na+ reabsorption in the distal nephron. The NEDD4L gene is located on human chromosome 18q21 within several blood pressure quantitative trait loci, including those for familial orthostatic hypotension, essential...

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Identifiers

PMID: 16103266
DOI: 10.1161/01.HYP.0000178594.63193.c0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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