Associations of genetic variations in NEDD4L with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults.

doi:10.1111/jch.14566

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Article

Associations of genetic variations in NEDD4L with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults.

Journal of clinical hypertension (Greenwich, Conn.) - 1 Oct 2022

Niu Ze-Jiaxin, Yao Shi, Zhang Xi, Mu Jian-Jun, Du Ming-Fei, Zou Ting, Chu Chao, Liao Yue-Yuan, Hu Gui-Lin, Chen Chen, Wang Dan, Ma Qiong, Yan Yu, Jia Hao, Wang Ke-Ke, Sun Yue, Yan Rui-Chen, Man Zi-Yue, Ren Dan-Feng, Wang Lan, Gao Wei-Hua, Li Hao, Wu Yong-Xing, Li Chun-Hua, Gao Ke, Zhang Jie, Yang Tie-Lin, Wang Yang

Abstract excerpt

Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L), a member of the E3 ubiquitin-protein ligases, encoded by NEDD4L gene, was found to be involved in in salt sensitivity by regulating sodium reabsorption in salt-sensitive rats. The authors aimed to explore the associations of NEDD4L genetic variants with salt sensitivity, blood pressure (BP) changes and hypertension incidence in Chinese...

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Identifiers

PMID: 36039789
DOI: 10.1111/jch.14566
PMCID: PMC9581093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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