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Differential Roles of p16INK4A and p14ARF Genes in Prognosis of Oral Carcinoma

1 Feb 2008

Abstract excerpt

BACKGROUND: Oral cancer patients are found to have poor clinical outcome and high disease recurrence rate, in spite of an aggressive treatment regimen. The inactivation of INK4A/ARF loci is reported to be second to p53 inactivation in human cancers. The purpose of this study was to assess the prognostic significance of the molecular aberrations in the INK4A locus for effective identification of aggressive oral...

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PMID: 18268126
DOI: 10.1158/1055-9965.epi-07-0284

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