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Article

Involvement ofINK4A gene products in the pathogenesis and development of human osteosarcoma

1 Jan 2001

Abstract excerpt

BACKGROUND: The INK4A tumor suppressor gene plays a crucial role in the regulation of the G1 cell cycle phase. It encodes two transcripts, p16 and p14 alternate reading frame (ARF), involved in retinoblastoma protein (pRb)- and p53- cell growth control pathways, respectively. METHODS: To define the role of gene status and molecule expression involved in the INK4A regulatory system, immunohistochemistry,...

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PMID: 11753985
DOI: 10.1002/1097-0142(20011215)92:12<3062::aid-cncr10161>3.0.co;2-x

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Involvement ofINK4A gene products in the pathogenesis and development of human osteosarcomaPMID 11753985Read ↗

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