Article
Methylation-Based Characterization of a New IDH2 Mutation in Sinonasal Undifferentiated Carcinoma.
International journal of molecular sciences - 13 Jun 2024
Burgermeister Simon, Stoykova Simona, Krebs Fanny S, Zoete Vincent, Mbefo Martial, Egervari Kristof, Reinhard Antoine, Bisig Bettina, Hewer Ekkehard
Abstract excerpt
Mutations affecting codon 172 of the isocitrate dehydrogenase 2 (IDH2) gene define a subgroup of sinonasal undifferentiated carcinomas (SNUCs) with a relatively favorable prognosis and a globally hypermethylated phenotype. They are also recurrent (along with IDH1 mutations) in gliomas, acute myeloid leukemia, and intrahepatic cholangiocarcinoma. Commonly reported mutations, all associated with aberrant IDH2...
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