Article
An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1.
Gastroenterology - 1 Nov 2008
Hanigan Christin L, Van Engeland Manon, De Bruine Adriaan P, Wouters Kim A, Weijenberg Matty P, Eshleman James R, Herman James G
Abstract excerpt
BACKGROUND & AIMS: Histone deacetylases (HDACs) are important regulators of chromatin involved in silencing tumor suppressor genes. We examined mutation of HDAC2 and examined consequences of HDAC2 loss. METHODS: Colon cancer cell lines and primary cancers were examined for mutations in HDAC2 by direct sequencing and capillary electrophoresis. Promoter methylation was determined using methylation-specific...
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