Article
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition.
Nature genetics - 1 May 2006
Ropero Santiago, Fraga Mario F, Ballestar Esteban, Hamelin Richard, Yamamoto Hiroyuki, Boix-Chornet Manuel, Caballero Rosalia, Alaminos Miguel, Setien Fernando, Paz Maria F, Herranz Michel, Palacios Jose, Arango Diego, Orntoft Torben F, Aaltonen Lauri A, Schwartz Simó, Esteller Manel
Abstract excerpt
Disruption of histone acetylation patterns is a common feature of cancer cells, but very little is known about its genetic basis. We have identified truncating mutations in one of the primary human histone deacetylases, HDAC2, in sporadic carcinomas with microsatellite instability and in tumors arising in individuals with hereditary nonpolyposis colorectal cancer syndrome. The presence of the HDAC2 frameshift...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.