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Article

Biochemical analysis of a common human polymorphism associated with age-related macular degeneration.

Biochemistry - 17 Jul 2007

Yu Jiamei, Wiita Patrick, Kawaguchi Riki, Honda Jane, Jorgensen Adam, Zhang Kang, Fischetti Vincent A, Sun Hui

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in developed countries. A large number of human genetic studies have associated a common variant (Y402H) of complement factor H (CFH) with a highly significant increase in AMD risk. CFH is a modular protein with 20 homologous short consensus repeats (SCRs). The Y402H variant is located in SCR7 of both CFH and factor H-like...

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Bacterial Proteins
C-Reactive Protein
Cell Line
Complement C3b Inactivator Proteins
Complement Factor H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macular Degeneration

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PMID: 17580967
DOI: 10.1021/bi700459a

Genes

CFH
CRP

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Biochemical analysis of a common human polymorphism associated with age-related macular degeneration.PMID 17580967Read ↗

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Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.Semantic proximity Read ↗

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