Article
Rapid detection of KIT mutations in core-binding factor acute myeloid leukemia using high-resolution melting analysis.
The Journal of molecular diagnostics : JMD - 1 Sept 2009
Fuster Oscar, Barragán Eva, Bolufer Pascual, Cervera José, Larráyoz Maria José, Jiménez-Velasco Antonio, Martínez-López Joaquín, Valencia Ana, Moscardó Federico, Sanz Miguel Angel
Abstract excerpt
The most frequent KIT mutations reported in core-binding factor acute myeloid leukemia are point mutations and insertions/deletions in exons 17 and 8. The vast majority of KIT mutation detection procedures are time-consuming, costly, or with a high lower limit of detection. High-resolution meltin...
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