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Article

The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2008

Zurita Adolfo R, Birnbaumer Lutz

Abstract excerpt

Mutating Arg-238 to Glu (R238E) in the switch 3 region of a transducin alpha (*Talpha) in which 27 aa of the GTPase domain have been replaced with those of the alpha-subunit of the inhibitory G protein 1 (Gi1alpha), was reported to create an alpha-subunit that is resistant to activation by GTPgammaS, is devoid of resident nucleotide, and has dominant negative (DN) properties. In an attempt to create a DN...

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Share to GTP-Binding Protein alpha Subunits

Share to GTP-Binding Protein alpha Subunits, Gs

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Identifiers

PMID: 18258741
DOI: 10.1073/pnas.0712261105
PMCID: PMC2268142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits.PMID 18258741Read ↗

A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor.Semantic proximity Read ↗

Mutation R238E in transducin-alpha yields a GTPase and effector-deficient, but not dominant-negative, G-protein alpha-subunit.Semantic proximity Read ↗

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Uncoupling of GTP binding from target stimulation by a single mutation in the transducin alpha subunit.Semantic proximity Read ↗

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