Article
Catalytic site mutations confer multiple states of G protein activation.
Science signaling - 14 Feb 2023
Hewitt Natalie, Ma Ning, Arang Nadia, Martin Sarah A, Prakash Ajit, DiBerto Jeffrey F, Knight Kevin M, Ghosh Soumadwip, Olsen Reid H J, Roth Bryan L, Gutkind J Silvio, Vaidehi Nagarajan, Campbell Sharon L, Dohlman Henrik G
Abstract excerpt
Heterotrimeric guanine nucleotide-binding proteins (G proteins) that function as molecular switches for cellular growth and metabolism are activated by GTP and inactivated by GTP hydrolysis. In uveal melanoma, a conserved glutamine residue critical for GTP hydrolysis in the G protein α subunit is often mutated in Gαq or Gα11 to either leucine or proline. In contrast, other glutamine mutations or mutations in...
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