Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alanine-23 of transducin alpha subunit is involved in defining the affinity for betagammma complex.

Neuroreport - 14 May 1999

Ho M K, Wong Y H

Abstract excerpt

Transducin alpha subunit (alpha(t)1) shows extraordinarily high affinity to G protein betagamma complex. One of the betagamma-binding regions on alphat1 is the amino-terminal helix. Alanine-23 is uniquely found on alphat1 but not other members of the Gi-subfamily. Mutation of alanine-23 into serine reduced the ability of alpha(t)1 to sequester betagamma-mediated stimulation of type II adenylyl cyclase. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Alanine
Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Proteins

Share to Peptide Fragments

Share to Serine

Share to Stimulation, Chemical

Share to Transducin

Source

Identifiers

PMID: 10380981
DOI: 10.1097/00001756-199905140-00031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alanine-23 of transducin alpha subunit is involved in defining the affinity for betagammma complex.PMID 10380981Read ↗

Alanine-23 of transducin alpha subunit is involved in defining the affinity for betagamma complex.Semantic proximity Read ↗

Uncoupling of GTP binding from target stimulation by a single mutation in the transducin alpha subunit.Semantic proximity Read ↗

The same mutation in Gsalpha and transducin alpha reveals behavioral differences between these highly homologous G protein alpha-subunits.Semantic proximity Read ↗

A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor.Semantic proximity Read ↗

Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin.Semantic proximity Read ↗

Dominant negative mutants of transducin-alpha that block activated receptor.Semantic proximity Read ↗

Structural Determinants of Constitutive Activation of Gα Proteins: Transducin as a Paradigm.Semantic proximity Read ↗

The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer.Semantic proximity Read ↗

Closely related G-protein-coupled receptors use multiple and distinct domains on G-protein alpha-subunits for selective coupling.Semantic proximity Read ↗

Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1).Semantic proximity Read ↗

Purification and characterization of the G203T mutant alpha i-2 subunit of GTP-binding protein expressed in baculovirus-infected Sf9 cells.Semantic proximity Read ↗

Effective information transfer from the alpha 1b-adrenoceptor to Galpha 11 requires both beta/gamma interactions and an aromatic group four amino acids from the C terminus of the G protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.