Article
A switch 3 point mutation in the alpha subunit of transducin yields a unique dominant-negative inhibitor.
The Journal of biological chemistry - 21 Oct 2005
Pereira Ryan, Cerione Richard A
Abstract excerpt
The rhodopsin/transducin-coupled vertebrate vision system has served as a paradigm for G protein-coupled signaling. We have taken advantage of this system to identify new types of constitutively active, transducin-alpha (alphaT) subunits. Here we have described a novel dominant-negative mutation, made in the background of a chimera consisting of alphaT and the alpha subunit of G(i1) (designated alphaT*), which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.