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Article

Dominant negative mutants of transducin-alpha that block activated receptor.

Biochemistry - 23 May 2006

Natochin Michael, Barren Brandy, Artemyev Nikolai O

Abstract excerpt

Mutations counterpart to dominant negative RasSer17Asn in the alpha-subunits of heterotrimeric G-proteins are known to also produce dominant negative effects. The mechanism of these mutations remains poorly understood. Here, we examined the effects and mechanism of the Ser43Cys and Ser43Asn mutants of transducin-like chimeric Gtalpha* in the visual signaling system. Our analysis showed that both mutants have...

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Identifiers

PMID: 16700559
DOI: 10.1021/bi060381e
PMCID: PMC2525804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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