Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of MYC stabilization in human malignancies

1 Mar 2008

Abstract excerpt

MYC is a pleiotropic transcription factor that has been linked to a diverse range of cellular functions, such as cell cycle regulation, proliferation, growth, differentiation and metabolism. Not surprisingly, aberrant MYC signaling has been observed in human cancers and MYC has been demonstrated to promote cell transformation and tumor progression. Here we discuss recent discoveries that have expanded our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18256542
DOI: 10.4161/cc.7.5.5492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of MYC stabilization in human malignanciesPMID 18256542Read ↗

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.Semantic proximity Read ↗

Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor MaintenanceSemantic proximity Read ↗

A CDCA2 - MYC positive feedback loop controls cancer cells survivalSemantic proximity Read ↗

MYC Deregulation in Primary Human CancersSemantic proximity Read ↗

MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and AgingSemantic proximity Read ↗

c-Myc as a therapeutic target in cancerSemantic proximity Read ↗

MYC: there is more to it than cancerSemantic proximity Read ↗

Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy TargetSemantic proximity Read ↗

Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradationSemantic proximity Read ↗

A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.Semantic proximity Read ↗

Myc proteins in brain tumor development and maintenance.Semantic proximity Read ↗

p27Kip1 and human cancers: A reappraisal of a still enigmatic protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.