Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance

1 Jul 2008

Abstract excerpt

MYC overexpression has been implicated in the pathogenesis of most types of human cancers. MYC is likely to contribute to tumorigenesis by its effects on global gene expression. Previously, we have shown that the loss of MYC overexpression is sufficient to reverse tumorigenesis. Here, we show that there is a precise threshold level of MYC expression required for maintaining the tumor phenotype, whereupon there is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Proteomics Techniques and Applications
Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18593912
DOI: 10.1158/0008-5472.can-07-6192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor MaintenancePMID 18593912Read ↗

Taking on challenging targets: making MYC druggable.Semantic proximity Read ↗

MYC Deregulation in Primary Human CancersSemantic proximity Read ↗

Mechanisms of MYC stabilization in human malignanciesSemantic proximity Read ↗

MYC: there is more to it than cancerSemantic proximity Read ↗

MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and AgingSemantic proximity Read ↗

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growthSemantic proximity Read ↗

MYC and therapy resistance in cancer: risks and opportunitiesSemantic proximity Read ↗

MYC Overexpression Drives Immune Evasion in Human Cancer that is Reversible Through Restoration of Pro-Inflammatory MacrophagesSemantic proximity Read ↗

MYCbase: a database of functional sites and biochemical properties of Myc in both normal and cancer cells.Semantic proximity Read ↗

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.Semantic proximity Read ↗

The ups and downs of Myc biologySemantic proximity Read ↗

c-Myc as a therapeutic target in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.