Article
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Nature cell biology - 1 Apr 2004
Yeh Elizabeth, Cunningham Melissa, Arnold Hugh, Chasse Dawn, Monteith Teresa, Ivaldi Giovanni, Hahn William C, Stukenberg P Todd, Shenolikar Shirish, Uchida Takafumi, Counter Christopher M, Nevins Joseph R, Means Anthony R, Sears Rosalie
Abstract excerpt
The stability of c-Myc is regulated by multiple Ras effector pathways. Phosphorylation at Ser 62 stabilizes c-Myc, whereas subsequent phosphorylation at Thr 58 is required for its degradation. Here we show that Ser 62 is dephosphorylated by protein phosphatase 2A (PP2A) before ubiquitination of c-Myc, and that PP2A activity is regulated by the Pin1 prolyl isomerase. Furthermore, the absence of Pin1 or inhibition...
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