Article
TP53 Arg72Pro, mortality after cancer, and all-cause mortality in 105,200 individuals.
Scientific reports - 23 Mar 2017
Kodal Jakob B, Vedel-Krogh Signe, Kobylecki Camilla J, Nordestgaard Børge G, Bojesen Stig E
Abstract excerpt
Rs1042522 (Arg72Pro) is a functional polymorphism of TP53. Pro72 has been associated with lower all-cause mortality and lower mortality after cancer. We hypothesized that TP53 Pro72 is associated with lower mortality after cancer, lower all-cause mortality, and with increased cancer incidence in the general population in a contemporary cohort. We genotyped 105,200 individuals aged 20-100 years from the Copenhagen...
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