Article
Differential effect of regional drug pressure on dihydrofolate reductase and dihydropteroate synthetase mutations in southern Mozambique.
The American journal of tropical medicine and hygiene - 1 Feb 2008
Raman Jaishree, Sharp Brian, Kleinschmidt Immo, Roper Cally, Streat Elizabeth, Kelly Val, Barnes Karen I
Abstract excerpt
The prevalence and frequency of the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) mutations associated with sulfadoxine-pyrimethamine (SP) resistance at 13 sentinel surveillance sites in southern Mozambique were examined regularly between 1999 and 2004. Frequency of the dhfr triple mutation increased from 0.26 in 1999 to 0.96 in 2003, remaining high in 2004. The dhps double mutation...
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